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标题：Involvement of Na+/Ca2+ Exchanger in Pentylenetetrazol-Induced Convulsion by Use of Na+/Ca2+ Exchanger Knockout Mice
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作者：Ryo Saito ; Erina Kaneko ; Yusuke Tanaka 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2009
卷号：32
期号：11
页码：1928-1930
DOI：10.1248/bpb.32.1928
出版社：The Pharmaceutical Society of Japan
摘要：Involvement of Na⁺/Ca²⁺ exchanger (NCX) in pentylenetetrazol (PTZ)-induced convulsion by use of NCX knockout mice and the selective ligand SEA0400 to NCX was examined. In the SEA0400-administered group, the latency to clonic convulsion was extended into 210 s, although the latency to clonic convulsion was observed until 100 s in control group. SEA0400 had little effect on bicuculline-induced clonic seizure nicotine-induced wild running and 4-aminopyridine-induced tonic flexion, respectively. Tonic flexion convulsion was occurred three fifth in the wild type mice group by administration of PTZ, but tonic flexion was not observed in NCX1 knockout mice groups. These results suggest that NCX is involved in inhibitory action in PTZ-induced convulsion.
关键词：Na+/Ca2+ exchanger;convulsion;knockout mouse;pentylenetetrazol