文章基本信息

标题：Antinociceptive Effect of Crude Extract, Fractions and Three Alkaloids Obtained from Fruits of Piper tuberculatum
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作者：Rosely Valéria Rodrigues ; Débora Lanznaster ; Daniela Tagliari Longhi Balbinot 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2009
卷号：32
期号：10
页码：1809-1812
DOI：10.1248/bpb.32.1809
出版社：The Pharmaceutical Society of Japan
摘要：This study investigated the possible antinociceptive effect of the crude extract, fractions and pure compounds (three alkaloids) obtained from fruits of Piper tuberculatum J ACQ . (Piperaceae) in acetic acid-induced visceral pain in mice. Oral administration of crude extract and fractions (CH₂Cl₂, EtOAc, methanol and hexane) (3—300 mg kg⁻¹) caused a dose-related and significant inhibition of the acetic acid-induced visceral nociceptive response. The crude extract, dichloromethane (CH₂Cl₂) and ethyl acetate (EtOAc) fractions were more potent than methanol and hexane fractions. The isolated alkaloids dihydro-piplartine, piplartine and 3,4,5-trimethoxydihydrocinnamic acid (0.0001—30 mg kg⁻¹) exhibited significant and dose-related antinociceptive effects against acetic acid-induced visceral pain. The results show, for the first time, that crude extract, fractions and pure compounds obtained from P. tuberculatum produce marked antinociception against the acetic acid-induced visceral nociceptive response, supporting the ethnomedical use of P. tuberculatum .
关键词：Piper tuberculatum;Piperaceae;alkaloid;pain;acetic acid