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标题：Anti-hepatitis B Virus Activities of Astragaloside IV Isolated from Radix Astragali
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作者：Shuguang Wang ; Jiyang Li ; Hai Huang 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2009
卷号：32
期号：1
页码：132-135
DOI：10.1248/bpb.32.132
出版社：The Pharmaceutical Society of Japan
摘要：Total ethanol extract and saponins from Chinese herb Radix Astragali (Huangqi) have been previously shown to possess anti-hepatitis B virus (HBV) activities in vitro . To identify the active ingredients, we isolated a triterpenoid saponin that was determined to be astragaloside IV. In the human HBV-transfected liver cell line HepG₂ 2.2.15, astragaloside IV effectively suppressed secretion of HBV antigens with inhibition rates of 23.6% for the secretion of Hepatitis B surface antigen (HBsAg) and 22.9% for that of Hepatitis B e antigen (HBeAg) at 100 μg/ml after 9 d of treatment. The inhibitory activity of astragaloside IV on secretion of HBV antigens is more potent than that of 3TC without significant cytotoxicity. In duck hepatitis B virus (DHBV)-infected ducklings, astragaloside IV caused 64.0% inhibition at 120 mg/kg, 49.6% inhibition at 40 mg/kg, and 41.7% inhibition at 10 mg/kg to serum DHBVs after 10 d of treatment, and also reduced serum DHBV DNA levels. Together, our results demonstrate that astragaloside IV possesses potent anti-HBV activity.
关键词：astragaloside IV;Radix Astragali;anti-hepatitis B virus activity