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标题：Effect of Propranolol on Hyphae Formation Signal in Candida albicans
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作者：Yukihiro Ueno ; Naoko Maruyama ; Mika Kanno 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2009
卷号：32
期号：1
页码：129-131
DOI：10.1248/bpb.32.129
出版社：The Pharmaceutical Society of Japan
摘要：Candida albicans ( C. albicans ) is known as an opportunistic pathogen that changes from a yeast form to a hyphae form in response to various outside environmental signals. The addition of propranolol inhibited hyphae formation of C. albicans . Propranolol inhibited the expression of agglutinin like sequence 3 (ALS3) and ALS8mRNA, which are regulated by the cAMP-EFG1 pathway in C. albicans . Propranolol did not affect the expression of CST20, HST7 or CPH1mRNA, which are components of the mitogen-activated protein (MAP) kinase cascade in C. albicans . The expression of CYR1mRNA, which encodes adenylate cyclase of C. albicans , was not affected by propranolol. These findings indicated that the interruption of hyphae formation by propranolol is caused by inhibition of the cAMP-EFG1 pathway, but not effects on the MAP kinase cascade.
关键词：Candida albicans;propranolol;EFG1;agglutinin like sequence 3;agglutinin like sequence 8