文章基本信息

标题：Anti-inflammatory and Analgesic Activities of Edgeworthia chrysantha and Its Effective Chemical Constituents
本地全文：下载
作者：Xiao-Jia Hu ; Hui-Zi Jin ; Wen-Zheng Xu 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2008
卷号：31
期号：9
页码：1761-1765
DOI：10.1248/bpb.31.1761
出版社：The Pharmaceutical Society of Japan
摘要：The barks and roots of Edgeworthia chrysantha L INDL ., which have been used as the folk medicine “Zhu shima” in southern China due to their detumescence and acesodyne effects, were investigated for their anti-inflammatory and analgesic activities using a xylene-induced ear edema assay in mice and Freund's complete adjuvant-induced paw edema as inflammation models, and the acetic acid-induced writhing test as an analgesic model. Fractions effective in terms of anti-inflammatory and analgesic activities were obtained from E. chrysantha . The chloroform-soluble fraction (CHF) showed significant anti-inflammatory ( p <0.01—0.001) and analgesic ( p <0.01) effects. On further purification by silica gel, three major coumarins, edgeworin (EdN), edgeworosides A and C (EdeA and EdeC), were isolated from the chloroform fraction and both anti-inflammatory and analgesic activities were evaluated. EdN and EdeA had anti-inflammatory ( p <0.05—0.01) and analgesic ( p <0.001) effects, while EdeC only showed an analgesic effect. The results of this study thus demonstrated that the coumarins EdN, EdeA and EdeC in this plant may be active constituents that contribute to the anti-inflammatory and analgesic effects.
关键词：Edgeworthia chrysantha;anti-inflammatory;analgesic;coumarin