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标题：Differential Regulation of the Antiapoptotic Action of B-Cell Lymphoma 2 (Bcl-2) and B-Cell Lymphoma Extra Long (Bcl-xL) by c-Jun N-Terminal Protein Kinase (JNK) 1-Involved Pathway in Neuroglioma Cells
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作者：Hyo-Soon Jeong ; Hye-Yeon Choi ; Tae-Won Choi 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2008
卷号：31
期号：9
页码：1686-1690
DOI：10.1248/bpb.31.1686
出版社：The Pharmaceutical Society of Japan
摘要：Here, we confirmed that stable expression of B-cell lymphoma-xL (Bcl-xL) in N18TG neuroglioma cells could suppress c-Jun N-terminal protein kinase (JNK) activation, nuclear fragmentation, and cell death caused by etoposide treatment. Moreover, additional overexpression of JNK1 led to partially antagonize the antiapoptotic environment attained by Bcl-xL, implying that JNK1-involved pathway may play a role in down-regulation of the antiapoptotic effect of Bcl-xL. However, the antagonistic effect of JNK1 on the antiapoptotic action of Bcl-xL was significantly weaker than that on the action of Bcl-2. Interestingly, we found that overexpression of JNK1 led to increase of Bcl-xL expression. Thus, these results suggest that Bcl-xL and Bcl-2 may induce its antiapoptotic effect in a different mechanism, provoking the possibility of involvement of JNK1-involved pathway in Bcl-xL expression.
关键词：apoptosis;antiapoptotic action;B-cell lymphoma extra long expression;etoposide;c-Jun N-terminal protein kinase signaling pathway