文章基本信息

标题：Inhibitory Effect of the Compounds Isolated from Rhus verniciflua on Aldose Reductase and Advanced Glycation Endproducts
本地全文：下载
作者：Eun Ha Lee ; Dae-Geun Song ; Joo Young Lee 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2008
卷号：31
期号：8
页码：1626-1630
DOI：10.1248/bpb.31.1626
出版社：The Pharmaceutical Society of Japan
摘要：The aim of this paper was to evaluate active principles for diabetic complications from Rhus verniciflua . Nine compounds were isolated via bioactivity guided fractionation and isolation and tested for their effects on recombinant human aldose reductase and advanced glycation endproducts. Butein and sulfuretin isolated from ethyl acetate fraction were found to possess strongly both forms of aldose reductase and advanced glycation endproducts inhibition. The inhibitory activity of butein against a recombinant human aldose reductase (IC₅₀ value: 0.5 μ M ) was 2.6 times more potent that of epalrestat as a positive control (IC₅₀ value: 1.3 μ M ). The inhibitory potency of sulfuretin (IC₅₀ value: 124.7 μ M ) on advanced glycation end-products was about 10 times more potent that of aminoguanidine as a positive control (IC₅₀ value: 1231.0 μ M ). These compounds all displayed antioxidative activity which was measured by Photochem^® apparatus. It was concluded, therefore, butein and sulfuretin have antioxidative as well as aldose reductase and advanced glycation endproducts inhibitory effects. As a result, these compounds could be proposed as a leading compound for further study as a new natural products drug that could be used for diabetic complications.
关键词：Rhus verniciflua;aldose reductase;advanced glycation endproduct;antioxidant;butein;sulfuretin