文章基本信息

标题：Sequential and Quantitative Analysis of a Murine Model of Elastase-Induced Emphysema
本地全文：下载
作者：Masaki Kawakami ; Yukiko Matsuo ; Kenta Yoshiura 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2008
卷号：31
期号：7
页码：1434-1438
DOI：10.1248/bpb.31.1434
出版社：The Pharmaceutical Society of Japan
摘要：Emphysema, one of chronic obstructive pulmonary disease (COPD), is characterized as destruction of airway wall and small airway inflammation. To assess the kinetics of disease progression in murine model of elastase-induced emphysema, we used micro-computed tomography (CT) compared with morphological changes. Two week after elastase administration, a significant increase in the volume of low-density areas, recognized as −800—−600 Hounsfield units by micro-CT, was observed. Coefficient of correlation between mean linear intercept (Lm) and low-density area examined by CT, was 0.79 ( p <0.01). Micro-CT can quantitatively and sequentially detect murine emphysematous changes, offering a practical method to sequentially analyze the therapeutic effects of treatments in a murine model of emphysema.
关键词：emphysema;computed tomography;elastase