文章基本信息

标题：An Attempt to Evaluate the Effect of Vitamin K3 Using as an Enhancer of Anticancer Agents
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作者：Sumio Matzno ; Yuka Yamaguchi ; Takeshi Akiyoshi 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2008
卷号：31
期号：6
页码：1270-1273
DOI：10.1248/bpb.31.1270
出版社：The Pharmaceutical Society of Japan
摘要：The possibility of vitamin K₃ (VK₃) as an anticancer agent was assessed. VK₃ dose-dependently diminished the cell viability (measured as esterase activity) with IC₅₀ of 13.7 μ M and Hill coefficient of 3.1 in Hep G2 cells. It also decreased the population of S phase and arrested cell cycle in the G₂/M phase in a dose-dependent manner. G₂/M arrest was regulated by the increment of cyclin A/cdk1 and cyclin A/cdk2 complex, and contrasting cyclin B/cdk1 complex decrease. Finally, combined application demonstrated that VK₃ significantly enhanced the cytotoxicity of etoposide, a G₂ phase-dependent anticancer agent, whereas it reduced the cytotoxic activity of irinotecan, a S phase-dependent agent. These findings suggest that VK₃ induces G₂/M arrest by inhibition of cyclin B/cdk1 complex formation, and is thus useful as an enhancer of G₂ phase-dependent drugs in hepatic cancer chemotherapy.
关键词：vitamin K3;hepatic cancer;G2/M arrest;etoposide