文章基本信息

标题：Satratoxin H Generates Reactive Oxygen Species and Lipid Peroxides in PC12 Cells
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作者：Punnee Nusuetrong ; Thitima Pengsuparp ; Duangdeun Meksuriyen 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2008
卷号：31
期号：6
页码：1115-1120
DOI：10.1248/bpb.31.1115
出版社：The Pharmaceutical Society of Japan
摘要：Satratoxin H, a mycotoxin, is thought to induce apoptosis of PC12 cells through the activation of p38 mitogen-activated protein kinase (MAPK) and c-Jun N-terminal kinase (JNK) in a glutathione (GSH)-sensitive manner. The present study was undertaken to further elucidate the mechanism by which satratoxin H induces cell death in PC12 cells. Satratoxin H caused apoptosis of PC12 cells within 24-h, as determined by DNA fragmentation and flow cytometric analysis. Satratoxin H increased reactive oxygen species (ROS) production and lipid peroxidation, as determined by malondialdehyde formation. These effects were attenuated by incubation of cells with GSH, suggesting that satratoxin H-induced increase in apoptosis of serum-deprived PC12 cells may be partially mediated through the generation of ROS.
关键词：Satratoxin H;reactive oxygen species;lipid peroxide;apoptosis;glutathione