文章基本信息

标题：Apoptosis-Inducing Effects of Two Anthraquinones from Hedyotis diffusa WILLD.
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作者：Ying Shi ; Chen-Hui Wang ; Xing-Guo Gong 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2008
卷号：31
期号：6
页码：1075-1078
DOI：10.1248/bpb.31.1075
出版社：The Pharmaceutical Society of Japan
摘要：Two anthraquinones which inhibit activity of the Src tyrosine kinase were isolated from a water extract of Hedyotis diffusa W ILLD. and identified as 2-hydroxy-3-methylanthraquinone (compound 1) and 1-methoxy-2-hydroxyanthraquinone (compound 2). Both compounds showed inhibitory activity against protein tyrosine kinases v-src and pp60src and arrested the growth of SPC-1-A, Bcap37 and HepG2 cancer cells. Observation of mitochondrial membrane potential collapse and caspase-3 activation following treatment with the compounds indicates that their apoptotic induction activity may act via the mitochondrial apoptotic pathway. Compared with compound 2, compound 1 is more active as an antagonist of Src kinase, which might account for its higher potency to induce growth arrest and apoptosis. These results provide a deeper insight into the functions of these two simple anthraquinones and the anti-tumour pathway of Hedyotis diffusa W ILLD .
关键词：Hedyotis diffusa;anthraquinone;apoptosis;c-src protein tyrosine kinase;mitochondrial membrane potential;caspase-3