文章基本信息

标题：Chemical Constituents of Morinda citrifolia Roots Exhibit Hypoglycemic Effects in Streptozotocin-Induced Diabetic Mice
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作者：Kohei Kamiya ; Wakako Hamabe ; Sachiko Harada 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2008
卷号：31
期号：5
页码：935-938
DOI：10.1248/bpb.31.935
出版社：The Pharmaceutical Society of Japan
摘要：The hypoglycemic effects of the chemical constituents of Morinda citrifolia roots was evaluated in streptozotocin (STZ)-induced diabetic mice. The CHCl₃, EtOAc, n -BuOH and H₂O soluble phases of the MeOH extract of M. citrifolia roots were administrated orally to STZ-induced diabetic mice. Only the n -BuOH soluble phase showed a significant reduction of the blood glucose levels. From the biologically active n -BuOH soluble phase, two iridoids and three anthraquinones were isolated as main constituents. These compounds were identified by spectroscopic analysis to be deacetylasperulosidic acid (1), asperulosidic acid (2), damnacanthol-3- O -β- D -primeveroside (3), lucidin 3- O -β- D -primeveroside (4) and morindone-6- O -β- D -primeveroside (5). 3 and 4 exhibited the hypoglycemic effects, which were anthraquinones with no substituents in one aromatic ring.
关键词：Morinda citrifolia;streptozotocin;hypoglycemic effect;anthraquinone glycoside