文章基本信息

标题：Biological Effects of a Sulfated-Polysaccharide Isolated from the Marine Red Algae Champia feldmannii
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作者：Ana Maria Sampaio Assreuy ; Daniel Magalhães Gomes ; Michelle Soares Josino da Silva 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2008
卷号：31
期号：4
页码：691-695
DOI：10.1248/bpb.31.691
出版社：The Pharmaceutical Society of Japan
摘要：Sulfated-polysaccharides are exploited as antithrombotic and anticoagulant agents and suggested to be immunostimulants. The sulfated-polysaccharide isolated from the red-marine-algae Champia feldmannii (Cf-PLS) was purified by ion exchange chromatography and tested in experimental protocols of coagulation, inflammation (in Wistar rats) and nociception (in Swiss mice). Cf-PLS was tested i.v. for its anti-inflammatory activity in the paw-edema induced by classical inflammatory stimuli and s.c. for its pro-inflammatory activity in the paw-edema and peritonitis models. The anticoagulant activity was evaluated by the test of partial thromboplastin activation time (aPTT) and the antinociceptive effect in the writhing-test. Cf-PLS was not anti-inflammatory, but rather induced maximal edematogenic activity at 0.9 mg/kg (1.01±0.030×0.06±0.03 ml) compared to controls (0.06±0.03 ml), increased vascular-permeability (38.44±12.63×11.29±3.91 μg/g) and stimulated neutrophil migration (3.348±295×307±99 cells/μl) 1 h after injection. Cf-PLS was also antinociceptive (6.6±1.28×33±1.44 writhes) and extended human plasma coagulation time by 3 times. Our data suggest that this molecule may be an important immunostimulant.
关键词：sulfated-polysaccharide;Champia feldmannii;inflammation;nociception;coagulation;marine algae