文章基本信息

标题：Inhibitory Constituents of Aldose Reductase in the Fruiting Body of Phellinus linteus
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作者：Yeon Sil Lee ; Young-Hee Kang ; Ju-Young Jung 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2008
卷号：31
期号：4
页码：765-768
DOI：10.1248/bpb.31.765
出版社：The Pharmaceutical Society of Japan
摘要：In an effort to characterize active principles for diabetic complication from medicinal mushroom, aldose reductase inhibitors were isolated from the fruiting body of Phellinus linteus and identified as hispidin (5), phelligridimer A (6), davallialactone (7), methyldavallialactone (8), hypholomine B (9), interfungins A (10), and inoscavin A (11), together with protocatechuic acid (1), protocatechualdehyde (2), caffeic acid (3), and ellagic acid (4). Their structures were elucidated by spectroscopic analyses. Among them, davallialactone (7), hypholomine B (9), and ellagic acid (4) exhibited potent rat lens aldose reductase and human recombinant aldose reductase inhibitory activity with IC₅₀ values of 0.33, 0.82, 0.63 μ M and 0.56, 1.28, 1.37 μ M , respectively.
关键词：diabetic complication;aldose reductase;Phellinus linteus;hispidin derivative