文章基本信息

标题：Antifungal Mechanism of Hinokitiol against Candida albicans
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作者：Nami Komaki ; Toshihiko Watanabe ; Ayako Ogasawara 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2008
卷号：31
期号：4
页码：735-737
DOI：10.1248/bpb.31.735
出版社：The Pharmaceutical Society of Japan
摘要：The growth of Candida albicans was dose-dependently inhibited by addition of hinokitiol. The sensitivity of C. albicans to hinokitiol under aerobic conditions was higher than that under anaerobic conditions. Amount of ATP in C. albicans was not inhibited by hinokitiol under both conditions. The expression of mRNAs related to the growth signal, CYR1 and RAS1, was inhibited by hinokitiol. These findings suggested that the growth inhibition of C. albicans by hinokitiol was due to the interruption of RAS-signal transmission, such as the cAMP pathway.
关键词：Candida albicans;hinokitiol;ATP;adenylate cyclase (CYR1);RAS1