文章基本信息

标题：Chloroquine, an Anti-malarial Agent, Acts as a Novel Regulator of β1-Integrin-Mediated Cell–Cell Adhesion
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作者：Jae Youl Cho
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2008
卷号：31
期号：4
页码：726-730
DOI：10.1248/bpb.31.726
出版社：The Pharmaceutical Society of Japan
摘要：Chloroquine is one of the disease-modifying antirheumatic drugs (DMARDs) with anti-malarial effect. In this study, we examined the modulatory effect of chloroquine on the functional activation of β1-integrins (CD29) using CD29- and CD98 (a functional regulator of CD29)-mediated U937 cell–cell adhesion, comparing macrophage functions and T cell proliferation. Chloroquine effectively suppressed U937 cell–cell adhesion mediated by CD29 and CD98, in a protein kinase (PK) C, PKA, protein tyrosine kinase (PTK), extracellular signal-regulated kinase (ERK) and actin cytoskeleton-independent manner. Other lysomotropic agents (monesin, methylamine and ammonium chloride) also significantly diminished both CD29- and CD98-mediated cell–cell adhesion, indicating that lysomotropic character may play a critical role in regulating β1-integrin functions. Therefore, these results suggest that chloroquine may act as a novel regulator of CD29 function in a lysomotropic character-dependent novel manner.
关键词：chloroquine;cell adhesion;CD29 (β1-integrins);CD98;lysomotropic agent