文章基本信息

标题：A Quinone Isolated from the Nest of Vespa simillima and Its Growth-Inhibitory Effect on Rat Liver Cancer Cells
本地全文：下载
作者：Yumiko Fujiwara ; Makoto Mangetsu ; Ping Yang 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2008
卷号：31
期号：4
页码：722-725
DOI：10.1248/bpb.31.722
出版社：The Pharmaceutical Society of Japan
摘要：A biologically active quinone that exhibits a growth-inhibitory effect on rat liver cancer cells was isolated from the nest of a social wasp, Vespa simillima (Vespinae, Vespidae). The structure was unambiguously determined by NMR and synthetic experiments and identified as being 7,8- seco - para -ferruginone. The synthetic quinone showed potent growth-inhibitory effects on rat hepatoma cells (IC₅₀ value=1.9 μ M ). Morphological analyses of dRLh84 cells using the synthetic compound were tested. Chromatin coagulation was induced by the synthetic compound at 31.6 μ M .
关键词：social wasp;nest material;quinone;cytotoxicity