文章基本信息

标题：Protective Effect of Lignans against Sepsis from the Roots of Saururus chinensis
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作者：Chang-Seob Seo ; Yeun-Kyung Lee ; Young-Jin Kim 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2008
卷号：31
期号：3
页码：523-526
DOI：10.1248/bpb.31.523
出版社：The Pharmaceutical Society of Japan
摘要：In the course of isolating preventive agents from sepsis based on the in vivo assay model from the EtOAc extract of the roots of Saururus chinensis , twelve lignans, sarisan (1), erythro -austrobailignan-6 (2), meso -dihydroguaiaretic acid (3), saucerneol B (4), manassantin B (5), manassantin A (6), rel -(8 R ,8′ R )-dimethyl-(7 S ,7′ R )-bis(3,4-methylenedioxyphenyl)tetrahydro-furan (7), (+)-saururinone (8), sauchinone (9), sauchinone B (10), nectandrin B (11) and machilin D (12), were isolated. Compounds 9 and 10, at a dose of 10 mg/kg, increased survival rates to 80% from 20% for the control experiment, and decreased the plasma levels of tumor necrosis factor-α (TNF-α) and alanine aminotransferase (ALT) activity in mice administered LPS/ D -GalN.
关键词：Saururus chinensis;sepsis;tumor necrosis factor-α;alanine aminotransferase activity