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  • 标题:Chemoprevention of Tumor Metastasis by Liposomal β-Sitosterol Intake
  • 本地全文:下载
  • 作者:Hiromichi Imanaka ; Hiroyuki Koide ; Kosuke Shimizu
  • 期刊名称:Biological and Pharmaceutical Bulletin
  • 印刷版ISSN:0918-6158
  • 电子版ISSN:1347-5215
  • 出版年度:2008
  • 卷号:31
  • 期号:3
  • 页码:400-404
  • DOI:10.1248/bpb.31.400
  • 出版社:The Pharmaceutical Society of Japan
  • 摘要:To investigate chemopreventive effect of liposomal β-sitosterol on tumor metastasis, we prepared liposomal β-sitosterol composed of egg yolk phosphatidylcholine for oral delivery. Although orally administered β-sitosterol (4 μmol as β-sitosterol/mouse) was not absorbed into plasma, the amount of immune response cytokines such as IL-12 and IL-18 was increased in the small intestine after the liposome intake. Moreover, after daily oral administration of the liposome for 7 d, natural killer (NK) cell activity in the mice was increased, suggesting that the immune surveillance activity of mice was enhanced by the liposomal β-sitosterol intake. Thus, we examined metastatic potential of B16BL6 melanoma cells, which were intravenously injected into mice after sequential administration of liposomal β-sitosterol for 7 d. The number of metastatic colonies in the lungs was significantly less than that of control group two weeks after the injections of the cells. These results suggest that daily liposomal β-sitosterol intake prevents tumor metastasis may be due to enhancement of gut immune surveillance systems.
  • 关键词:liposome;sitosterol;oral delivery;tumor metastasis;chemoprevention
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