文章基本信息

标题：Treatment of Ewing's Sarcoma Using an Antisense Oligodeoxynucleotide to Regulate the Cell Cycle
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作者：Satoru Asami ; Motoaki Chin ; Hiroyuki Shichino 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2008
卷号：31
期号：3
页码：391-394
DOI：10.1248/bpb.31.391
出版社：The Pharmaceutical Society of Japan
摘要：Ewing's sarcoma (ES) is one of the most malignant tumors of bone and soft tissue in children and young adults. ES belongs to a group of small round cell tumors (SRCTs) that also includes neuroblastoma, rhabdomyosarcoma, and malignant lymphoma. However, ES exhibits several specific chimeric genes ( EWS – FLI1 , EWS – ERG , EWS – ETV1 , EWS – E1AF , and EWS – FEV ) caused by chromosomal translocations that are not shared by other SRCTs. These chimeric genes regulate the expression of various other genes; that is, they activate inhibitors of DNA binding 2 ( Id2 ) gene expression or they suppress transforming growth factor β II ( TβRII ) receptor gene expression. The regulation of these chimeric genes may affect critical cell signal transductions, such as signals involved in cell cycle and apoptosis in ES tumor cells. Using an antisense oligodeoxynucleotide against a sequence containing the ATG initiation codon of the EWS – FLI1 chimeric gene that specifically reacts with the EWS – FLI1 and EWS – ERG chimeric genes, we were able to regulate the cell cycle through the down-regulation of Id2 . Here, we report that treatment with an antisense oligodeoxynucleotide against this chimeric gene was very useful for inducing the regression of ES tumor growth; thus, this chimeric gene may be an important target for the treatment of ES patients.
关键词：Ewing's sarcoma family tumor;EWS–ets chimeric gene;antisense oligodeoxynucleotide;cell cycle