文章基本信息

标题：Hepatoprotective Effect of Vitamin B12 on Dimethylnitrosamine-Induced Liver Injury
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作者：Katsuhiro Isoda ; Noritaka Kagaya ; Soichiro Akamatsu 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2008
卷号：31
期号：2
页码：309-311
DOI：10.1248/bpb.31.309
出版社：The Pharmaceutical Society of Japan
摘要：Vitamin B₁₂ contains a cobalt complex and accumulates at high levels in the liver. Vitamin B₁₂ was examined for its hepatoprotective effect on dimethylnitrosamine-induced liver injury in mice. Vitamin B₁₂ decreased the blood levels of aspartate aminotransferase and alanine aminotransferase, and clearly inhibited the overaccumulation of collagen fibrils. Reverse transcription-polymerase chain reaction (RT-PCR) analysis of the liver showed that the gene expression of α-smooth muscle actin and heat-shock protein 47, which are markers of fibrosis, were suppressed by vitamin B₁₂ administration. Our findings indicate that vitamin B₁₂ could be an effective hepatoprotective agent.
关键词：hepatoprotection;vitamin B12;liver fibrosis;metal complex