文章基本信息

标题：Clarithromycin Inhibits Progeny Virus Production from Human Influenza Virus-Infected Host Cells
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作者：Daisei Miyamoto ; Sayaka Hasegawa ; Nongluk Sriwilaijaroen 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2008
卷号：31
期号：2
页码：217-222
DOI：10.1248/bpb.31.217
出版社：The Pharmaceutical Society of Japan
摘要：In vitro effects of macrolide clarithromycin (CAM) on influenza A virus-infected cells were examined using plaque reduction assay by treating cells either before or after viral adsorption. The significant inhibitory effect on influenza virus infection was detected only when the cells were treated with CAM after viral adsorption. The predominant inhibitory effect was observed during 4—7th hour after viral adsorption using viral production assay. CAM did not exhibit inhibitory effects on influenza virus hemagglutination, membrane fusion and viral sialidase activities. These findings indicate that CAM acts on a middle to late stage of the viral replication cycle resulting in inhibition of progeny virus production from the infected cells.
关键词：clarithromycin;influenza virus;anti-influenza drug