文章基本信息

标题：Low Density Lipoprotein (LDL)-Antioxidant Flavonoids from Roots of Sophora flavescens
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作者：Tae-Sook Jeong ; Young Bae Ryu ; Hoi Young Kim 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2008
卷号：31
期号：11
页码：2097-2102
DOI：10.1248/bpb.31.2097
出版社：The Pharmaceutical Society of Japan
摘要：Oxidation of low density lipoprotein (LDL) is strongly implicated as a key process in the onset of atherosclerosis. In this study, nine alkylated (C₁₀–C₅) flavonoids from Sophora flavescens were examined for their inhibitory effects on copper-induced LDL oxidation. Of the flavonoids tested, sophoraflavanone G (1), kurarinone (2), kurarinol (3), norkurarinol (4), and kuraridin (9) inhibited the generation of thiobarbituric acid reactive substances (TBARS) with IC₅₀s of 7.9, 14.5, 22.0, 26.9, and 17.5 μ M , respectively. The most potent inhibitor, compound 1, also demonstrated significant activities in complementary in vitro investigations, such as lag time (130 min at 5 μ M ), relative electrophoretic mobility (REM) of ox-LDL (80% inhibition at 20 μ M ), and fragmentation of apoB-100 (inhibition of 71% at 20 μ M ). Analysis of the structures of these compounds reveals that a resorcinol moiety in the B-ring is strongly correlated with protection of LDL-oxidation.
关键词：Sophora flavescens;low density lipoprotein oxidation;sophoraflavanone G;kurarinone;resorcinol