文章基本信息

标题：Anti-proliferative Effect of Licochalcone A on Vascular Smooth Muscle Cells
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作者：Jin-Hee Park ; Hyun Joung Lim ; Kuy-Sook Lee 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2008
卷号：31
期号：11
页码：1996-2000
DOI：10.1248/bpb.31.1996
出版社：The Pharmaceutical Society of Japan
摘要：Licochalcone A, a flavonoid found in licorice root ( Glycyrrhiza glabra ), is known for its anti-microbial activity and its reported ability to inhibit cancer cell proliferation. In the present study, we investigated whether licochalcone A inhibits rat vascular smooth muscle cell (rVSMC) proliferation. Our data indicate that 5 μ M licochalcone A inhibited platelet-derived growth factor (PDGF)-induced rVSMC proliferation, possibly through its ability to block the progression of the cell cycle from G₁ to S phase. In addition, 5 μ M licochalcone A significantly inhibited the PDGF-induced expression of cyclin A, cyclin D1, CDK2, and CDK4, and the phosphorylation of Rb. Licochalcone A also reversed the decrease in p27^kip1 expression reduced by PDGF. Finally, licochalcone A inhibited the PDGF-induced activation of extracellular signal-regulated kinase (ERK)1/2. Together, these data provide the first evidence that licochalcone A can regulate rVSMC proliferation and suggest that licochalcone A inhibits the proliferation of rVSMCs by suppressing the PDGF-induced activation of the ERK1/2 pathway and Rb phosphorylation, resulting in cell cycle arrest.
关键词：licochalcone A;cellular proliferation;cell cycle;smooth muscle cell