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标题：Antimicrobial Effects of Drugs against Multidrug-Resistant Pseudomonas aeruginosa
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作者：Kumiko Maeda ; Youko Kobayashi ; Shigeharu Oie 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2008
卷号：31
期号：10
页码：1898-1901
DOI：10.1248/bpb.31.1898
出版社：The Pharmaceutical Society of Japan
摘要：We evaluated the effects of antimicrobial drugs on four strains of Pseudomonas aeruginosa that are resistant to eight widely used antipseudomonal drugs (piperacillin, piperacillin-tazobactam, imipenem, meropenem, ceftazidime, aztreonam, amikacin, ciprofloxacin) and colistin. In the killing test, colistin (2 μg/ml) was the most effective, followed by aztreonam (48 μg/ml), piperacillin-tazobactam (192—4 μg/ml), piperacillin (192 μg/ml), and a three drug combination of azetreonam (16 μg/ml), ceftazidime (16 μg/ml), and amikacin (4 μg/ml). Six hours after drug addition, colistin (2 μg/ml), aztreonam (48 μg/ml), piperacillin-tazobactam (192—4 μg/ml), piperacillin (192 μg/ml), and the above three drug combination had bacteriostatic effects on all four strains. Colistin, three time breakpoint of aztreonam, piperacillin, or piperacillin-tazobactam, and the three drug combination of aztreonam, ceftazidime, and amikacin were effective in vitro .
关键词：Pseudomonas aeruginosa;multidrug-resistant;aztreonam;ceftazidime;amikacin;combined effect