文章基本信息

标题：Cryptomeria japonica-Induced Allergic Conjunctivitis in Mice
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作者：Atsuki Fukushima ; Daisuke Shii ; Tamaki Sumi 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2007
卷号：30
期号：9
页码：1745-1747
DOI：10.1248/bpb.30.1745
出版社：The Pharmaceutical Society of Japan
摘要：Japanese cedar pollen ( Cryptomeria japonica , Cry j) is the most common allergen causing pollinosis in Japan. However, short ragweed pollen is used commonly as the antigen for experimentally-induced allergic conjunctivitis (EC) and Cry j-induced EC in mice has not been published. We actively immunized BALB/c mice with Cry j, and then performed a challenge with eye drops containing Cry j. We evaluated the early phase and late phase reactions in the conjunctiva, using Evans blue dye leakage and eosinophil infiltration, respectively. Significant inhibition of the early phase reaction was observed following pre-challenge with eye drops that block histamine H1 receptor in the conjunctiva. Thus, Cry j-induced EC appears to represent a suitable model for the study of pollinosis in Japan.
关键词：allergic conjunctivitis;cryptomeria japonica;histamine H1 receptor blocker;early phase reaction;late phase reaction