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标题：Suppression of AP-1 Activity by Cycloprodigiosin Hydrochloride
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作者：Keiko Kawauchi ; Kei Tobiume ; Shuhei Kaneko 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2007
卷号：30
期号：9
页码：1792-1795
DOI：10.1248/bpb.30.1792
出版社：The Pharmaceutical Society of Japan
摘要：Cycloprodigiosin hydrochloride (cPrG·HCl), a compound isolated from a marine bacterium, acts as an immunosuppressant and an anti-cancer drug. We have previously reported that cPrG·HCl suppressed the transcriptional activation of nuclear factor (NF)-κB. Here we studied the effect of cPrG·HCl on activation of another transcription factor, activator protein 1 (AP-1). cPrG·HCl potently suppressed AP-1 activity induced by tumor necrosis factor (TNF) α and phorbol myristate acetate (PMA). cPrG·HCl did not inhibit any of the mitogen-activated protein kinase (MAPK) families, whereas it did suppress transcriptional activation of AP-1 induced by constitutively activated mutants of MEKK1 or Ras. cPrG·HCl inhibited neither TNFα- or PMA-induced DNA-binding of AP-1 nor co-activator p300-induced activation of AP-1. Taken together, cPrG·HCl suppresses AP-1-dependent gene expression downstream of MAPK group through the inhibition of the transcription activation step of the AP-1 promoter complex.
关键词：prodigiosin;activator protein 1;nuclear factor (NF)-κB;mitogen-activated protein kinase