文章基本信息

标题：Effect of Permeation Enhancers on the in Vitro Percutaneous Absorption of Pentazocine1)
本地全文：下载
作者：Takayuki Furuishi ; Sachiko Oda ; Hiroaki Saito 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2007
卷号：30
期号：7
页码：1350-1353
DOI：10.1248/bpb.30.1350
出版社：The Pharmaceutical Society of Japan
摘要：The effect of permeation enhancers on the percutaneous absorption of pentazocine (PTZ) was investigated in excised hairless mice using Franz diffusion cells in vitro . The enhancing effect on the percutaneous absorption of PTZ from the isopropyl myristate (IPM) solution system was improved with glyceryl monocaprylate (GEFA-C₈), which is a kind of glycerol ester of fatty acid (GEFA). The flux of PTZ through the skin was ca. 4 times higher compared with IPM alone, while a less enhancing effect of glyceryl dicaprylate (GEFA-DiC₈) and glyceryl tricaprylate (GEFA-TriC₈) on the skin permeation of PTZ was found. Moreover, maximum enhancement of PTZ flux was observed with glyceryl monocaproate (GEFA-C₆) among various alkyl chains (C₂—C₁₈) of monoglycerides. These results indicated that the IPM solution system combination with GEFA may be used to develop a transdermal formulation with improved skin permeation of PTZ.
关键词：pentazocine;permeation enhancer;isopropyl myristate;glycerol ester;hydrophilic-lipophilic balance (HLB)