文章基本信息

标题：Vasorelaxant Effects of Acer nikoense Extract and Isolated Coumarinolignans on Rat Aortic Rings
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作者：Toru Iizuka ; Seiji Nagumo ; Hideomi Yotsumoto 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2007
卷号：30
期号：6
页码：1164-1166
DOI：10.1248/bpb.30.1164
出版社：The Pharmaceutical Society of Japan
摘要：The organic extract of the heartwood of Acer nikoense M AXIM . (Aceraceae) showed vasorelaxant activity on rat aorta with or without endothelium. Coumarin [scopoletin (1)] and coumarinolignans [cleomiscosin A (2) and aquillochin (3)] were isolated as major constituents from the organic extract of the heartwood of A. nikoense . Compounds 1—3 exhibited moderate vasorelaxant effects on rat aorta, while 2 and 3 showed vasorelaxant effects in the norepinephrine-stimulated and also in high K⁺-depolarized preparations.
关键词：Acer nikoense;coumarinolignan;cleomiscosin A;aquillochin;vasorelaxant effect;aorta