文章基本信息

标题：Magnoflorine from Coptidis Rhizoma Protects High Density Lipoprotein during Oxidant Stress
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作者：Tran Manh Hung ; Jong Pill Lee ; Byung Sun Min 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2007
卷号：30
期号：6
页码：1157-1160
DOI：10.1248/bpb.30.1157
出版社：The Pharmaceutical Society of Japan
摘要：The objective of the present study was to investigate the beneficial properties of magnoflorine, an alkaloid isolated from Coptidis Rhizoma, on protecting human high density lipoprotein (HDL) against lipid peroxidation. Magnoflorine exerts an inhibitory effect against Cu²⁺-induced lipid peroxidation of HDL, as showed by prolongation of lag time from 62 to 123 min at the concentration of 3.0 μ M . It also inhibits the generation of thiobarbituric acid reactive substances (TBARS) in the dose-dependent maners with IC₅₀ values of 2.3±0.2 μ M and 6.2±0.5 μ M since HDL oxidation mediated by either catalytic Cu²⁺ or thermo-labile radical initiator (AAPH), respectively. Separately, Cu²⁺ oxidized HDL lost the antioxidant action but the inclusion of magnoflorine/Cu²⁺ oxidized HDL can protect LDL oxidation according to increasing magnoflorine concentration. The results suggest that magnoflorine may have a role to play in preventing the HDL oxidation.
关键词：Coptidis Rhizoma;magnoflorine;cardiovascular disease;high density lipoprotein;antioxidant