文章基本信息

标题：Inhibitory Effect of Schizandrin on Passive Cutaneous Anaphylaxis Reaction and Scratching Behaviors in Mice
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作者：Bomi Lee ; Eun-Ah Bae ; Hien Trung Trinh 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2007
卷号：30
期号：6
页码：1153-1156
DOI：10.1248/bpb.30.1153
出版社：The Pharmaceutical Society of Japan
摘要：To evaluate the antiallergic effect of the fruit of Schizandra chinensis B AILL (Family Magnoliaceae), which inhibited the mouse passive cutaneous anaphylaxis (PCA) reaction in a preliminary experiment, its main constituent, schizandrin, was isolated and its antiallergic effect investigated. Schizandrin inhibited the PCA reaction induced by the IgE–antigen complex, the scratching behaviors induced by compound 48/80 and the serum IgE production induced by ovalbumin. Schizandrin also inhibited the in vitro degranulation of compound 48/80-induced rat peritoneal mast cells and IgE-induced RBL 2H3 cells. Schizandrin reduced the protein expressions of TNF-α and IL-4 in IgE-induced RBL 2H3 cells. These findings suggest that schizandrin can improve IgE-induced anaphylaxis and scratching behaviors.
关键词：allergy;schizandrin;anaphylaxis;IgE