文章基本信息

标题：Apple Extracts Present Catabolic and Hipocolesterolemic Effect in Mice
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作者：Mauricio Poblete 1 , Amalia Neira 2 , Ricardo Huilcamán 1 , Iván Palomo 1,3 , Jose Antonio Yuri 2,3 , Rodrigo Moore-Carrasco 1,
期刊名称：Food and Nutrition Sciences
印刷版ISSN：2157-944X
电子版ISSN：2157-9458
出版年度：2015
卷号：06
期号：01
页码：141-150
DOI：10.4236/fns.2015.61015
语种：English
出版社：Scientific Research Publishing
摘要：Dyslipidemia is highly prevalent in the Chilean population: about 40% have total cholesterol levels over 200 mg/dl and 25% are obese (BMI > 30) which produces an increased risk of cardiovascular disease and deaths. Over consumption of foods rich in lipids and carbohydrates unchains these events, due to the high amount of lipid accumulation in adipocytes. These cells are capable of producing a large number of mediators of inflammation and adipokines which in large quantities can compromise the overall metabolism. Apple has been shown to stop these events. We used CF-1 mice that were fed on a high-fat diet which leads to a metabolic status similar to dyslipidemia. Different types of apple waste were direct from orchard and fruit industry. Extracts obtained were characterized and administered in drinking water. At the end of the 40-day experimental period, biochemical parameters in animals were measured and the weight of white adipose tissue (WAT) was quantified. The results were compared with the normal diet and fat diet controls. All apple extracts decrease total and LDL cholesterol to levels similar to normal control and decrease WAT. Apple extracts may be an effective protector against development of risk factors in cardiovascular disease in the Chilean population.
关键词：Cholesterol; Apple; Antioxidants and Metabolic Syndrome