文章基本信息

标题：Dynamics of a Breast Cancer Model for Neutropenia Case due to Chemotherapy Effects
本地全文：下载
作者：Fathoni, M. Ivan Ariful ; Adi-Kusumo, Fajar ; Gunardi, Gunardi 等
期刊名称：Differential Equations and Nonlinear Mechanics
印刷版ISSN：1687-4099
电子版ISSN：1687-4102
出版年度：2021
卷号：2021
DOI：10.1155/2021/3401639
语种：English
出版社：Hindawi Publishing Corporation
摘要：Breast cancer is a type of carcinoma with a high prevalence. The treatment of breast cancer through chemotherapy can cause a risk to healthy cells throughout the body. The neutrophil is one of the cells that is influenced by chemotherapy drugs. Chemotherapy-induced neutropenia is one of the most common toxic effects experienced by patients and often threatens chemotherapy to use efficiency. In this paper, we introduce an interaction model between blood components, i.e., neutrophil, lymphocytes, and albumin, with chemotherapy drugs. The model is important to understand the neutropenia effect due to chemotherapy in mathematical perspective and to calculate breast cancer patients’ survival level. Our model is a four-dimensional system of the first-order ODE with 13-dimensional parameter space. We focus our study for understanding the steady-state conditions and the bifurcations when the parameter values are varied. Here, we also study the role of albumin for reducing the neutropenia effects for breast cancer patients mathematically, where the results can be used as an alternative solution for treating neutropenia in a breast cancer case.