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标题：Differential Antiviral Activity of Benzastatin C and Its Dechlorinated Derivative from Streptomyces nitrosporeus
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作者：Jong-Gyo Lee ; Ick-Dong Yoo ; Won-Gon Kim 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2007
卷号：30
期号：4
页码：795-797
DOI：10.1248/bpb.30.795
出版社：The Pharmaceutical Society of Japan
摘要：Benzastatin C, a 3-chloro-tetrahydroquinolone alkaloid from Streptomyces nitrosporeus , showed antiviral activity in a dose-dependant manner with EC₅₀ values of 1.92, 0.53, and 1.99 μg/ml against herpes simplex virus type 1 (HSV-1), herpes simplex virus type 2 (HSV-2), and vesicular stomatitis virus (VSV), respectively. In contrast, benzastatin D, the corresponding dechlorinated derivative, did not exhibit any antiviral activity. These results indicate that the antiviral activity of benzastatin C is mediated, in part, due to the chlorine moiety in its molecular structure.
关键词：benzastatin C;antiviral activity;Streptomyces nitrosporeus;chloro-tetrahydroquinolone