文章基本信息

标题：Induction of Metallothionein Synthesis by Cilostazol in Mice and in Human Cultured Neuronal Cell Lines
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作者：Shinya Suzuki ; Yosuke Masui ; Mieko Ohnuki 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2007
卷号：30
期号：4
页码：791-794
DOI：10.1248/bpb.30.791
出版社：The Pharmaceutical Society of Japan
摘要：In this study, we examined the effect of Cilostazol to induce metallothionein (MT) in vivo and in vitro . Intraperitoneal injection of Cilostazol increased the expression of both MT-1 and MT-2 mRNA and total MT protein in the mouse liver. Cilostazol also augmented MT-1 mRNA levels in the murine brain. In vitro exposure to Cilostazol significantly augmented intracellular MT protein levels in cultured human brain microvascular endothelial cells (HBMEC) and in the neuroblastoma cell line IMR32. Taken together, these findings suggest that Cilostazol is an inducer of MT in the murine liver and brain, and that it has the potential to directly induce MT in cells. The contribution of the anti-oxidative effect of MT to the anti-stroke effect of Cilostazol was discussed.
关键词：metallothionein;cilostazol;brain