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标题：VEGF-C and VEGF-A Synergistically Enhance Lymph Node Metastasis of Gastric Cancer
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作者：Kenji Kondo ; Takeshi Kaneko ; Megumi Baba 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2007
卷号：30
期号：4
页码：633-637
DOI：10.1248/bpb.30.633
出版社：The Pharmaceutical Society of Japan
摘要：Purpose: Vascular endothelial growth factor C (VEGF-C) is the most important molecule in lymphangiogenesis and its relationship with lymph node metastasis has attracted considerable interest. We investigated the relationship of VEGF-C or VEGF-A with clinicopathological factors in gastric cancer patients. Methods: Eighty gastric cancer patients who underwent gastric resection were analyzed immunohistochemically for expression of VEGF-C and VEGF-A protein. Results: Positive immunoreactivity of VEGF-C and VEGF-A was observed in 75 (93.8%) and 41 (51.3%) patients, respectively. VEGF-A expression was significantly correlated with tumor differentiation ( p =0.0017) and vascular invasion ( p =0.0004). And positive relationship of VEGF-C expression was only demonstrated with tumor differentiation ( p =0.0168). Interestingly, however, the frequency of lymph node metastasis was significantly higher in the patients with expression of both VEGF-C and VEGF-A (strong positive expression, p =0.036). Furthermore, the expression of both was also significantly correlated with depth of tumor invasion, tumor differentiation, lymphatic invasion, and vascular invasion. Conclusion: The present results suggest that strong expression of VEGF-A in addition to VEGF-C expression is essential in lymph node metastasis, presumably because enhanced metastatic potential including lymphangiogenesis induced by both VEGF-A and VEGF-C is vital in lymph node metastasis of gastric cancer.
关键词：vascular endothelial growth factor (VEGF)-C;VEGF-A;gastric cancer;lymph node metastasis