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标题：Cerebral Protective and Cognition-Improving Effects of Sinapic Acid in Rodents
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作者：Fumito Karakida ; Yukinobu Ikeya ; Mitsuo Tsunakawa 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2007
卷号：30
期号：3
页码：514-519
DOI：10.1248/bpb.30.514
出版社：The Pharmaceutical Society of Japan
摘要：We previously demonstrated that tenuifoliside B and 3,6′-disinapoylsucrose in Polygalae Radix, the root of Polygala tenuifolia W ILLDENOW , inhibited potassium cyanide (KCN)-induced hypoxia and scopolamine-induced memory impairment in mice. Because both ingredients have a common sinapoyl moiety in their structure, we inferred that the sinapoyl moiety could inhibit hypoxia and memory impairment. In the present study to clarify the hypothesis, sinapic acid inhibited KCN-induced hypoxia and scopolamine-induced memory impairment as well as tenuifoliside B and 3,6′-disinapoylsucrose did. In addition, sinapic acid inhibited decompression- or bilateral carotid artery ligation-induced hypoxia (or mortality) and CO₂-induced impairment in mice, and basal forebrain lesion-induced cerebral cholinergic dysfunction (decreases in acetylcholine concentration and choline acetyltransferase activity) in rats. These results, taken together, suggest the possibilities that sinapic acid is not only a very important moiety in the pharmacological activities of tenuifoliside B and 3,6′-disinapoylsucrose but also a candidate for a cerebral protective and cognition-improving medicine.
关键词：Polygalae Radix;sinapic acid;memory impairment;anoxia;acetylcholine;choline acetyltransferase