文章基本信息

标题：Inhibitory Effects of Methyl Brevifolincarboxylate Isolated from Phyllanthus niruri L. on Platelet Aggregation
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作者：Toru Iizuka ; Masahiro Nagai ; Akemi Taniguchi 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2007
卷号：30
期号：2
页码：382-384
DOI：10.1248/bpb.30.382
出版社：The Pharmaceutical Society of Japan
摘要：A platelet-aggregatory inhibitor was isolated from the 50% MeOH extract of Phyllanthus niruri L. leaf. Its structure was determined to be methyl brevifolincarboxylate on the basis of the ¹H-, ¹³C-NMR, and high-resolution mass spectral data. We compared the antiplatelet aggregatory effects of the constituent with adenosine, a well-known inhibitor of platelet aggregation. Platelet aggregation was induced by collagen or adenosine 5′-diphosphate as an activating agent; the extent of inhibition was monitored with a platelet aggregometer employing a laser-scattering method. The inhibitory effects of methyl brevifolincarboxylate were found to be as potent as adenosine that is known to act on an A_2A subtype receptor.
关键词：Phyllanthus niruri;methyl brevifolincarboxylate;platelet aggregation;inhibitory effect