文章基本信息

标题：Potentiation of Antimicrobial Activity of Aminoglycosides by Carnosol from Salvia officinalis
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作者：Kumiko Horiuchi ; Sumiko Shiota ; Teruo Kuroda 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2007
卷号：30
期号：2
页码：287-290
DOI：10.1248/bpb.30.287
出版社：The Pharmaceutical Society of Japan
摘要：We found that a crude extract from Salvia officinalis (sage) reduced the minimum inhibitory concentrations (MICs) of aminoglycosides in vancomycin-resistant enterococci (VRE). We isolated the effective compound from the extract and identified it as carnosol, one of diterpenoids. Carnosol showed a weak antimicrobial activity, and greatly reduced the MICs of various aminoglycosides (potentiated the antimicrobial activity of aminoglycosides) and some other types of antimicrobial agents in VRE. Carnosic acid, a related compound, showed the similar activity. The effect of carnosol and carnosic acid with gentamicin was synergistic.
关键词：carnosol;carnosic acid;aminoglycoside;vancomycin-resistant enterococci (VRE)