文章基本信息

标题：Hyphal Formation of Candida albicans Is Inhibited by Salivary Mucin
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作者：Ayako Ogasawara ; Nami Komaki ; Hitoshi Akai 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2007
卷号：30
期号：2
页码：284-286
DOI：10.1248/bpb.30.284
出版社：The Pharmaceutical Society of Japan
摘要：When mucin was added to Candida albicans under hyphal growth conditions, the hyphal formation was inhibited. After the 24 h incubation, the ratio of hyphal cells was 95.7±1.13% in the absence of mucin and no hyphal cells were observed in the presence of 1000 μg/ml mucin. The ratio of hyphal cells began to decreases at 6 h in the mucin addition group. Although mucin has antifungal activity, the concentration of mucin used in this assay did not inhibit the growth of C. albicans , indicating that the inhibition of hyphal formation was not due to the inhibition of germination by its antifungal activity. Expression of RAS1 mRNA in C. albicans was inhibited by mucin. These results suggest that the inhibition of hyphal formation by mucin was caused by interruption of the hyphal formation signal of C. albicans .
关键词：Candida albicans;mucin;transformation;RAS1mRNA;EFG1mRNA