文章基本信息

标题：Effects of the Serotonin and Noradrenaline Reuptake Inhibitor (SNRI) Milnacipran on Marble Burying Behavior in Mice
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作者：Yumi Sugimoto ; Noriko Tagawa ; Yoshiharu Kobayashi 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2007
卷号：30
期号：12
页码：2399-2401
DOI：10.1248/bpb.30.2399
出版社：The Pharmaceutical Society of Japan
摘要：The effects of milnacipran, a serotonin and noradrenaline reuptake inhibitor (SNRI) on the obsessive compulsive disorder (OCD) model, marble burying behavior, were investigated in mice. Milnacipran above the dosage of 10 mg/kg inhibited marble burying behavior significantly in mice as similar to fluvoxamine. Milnacipran inhibiting marble burying behavior did not affect locomotor activity. These results suggest that milnacipran can inhibit marble burying behavior and that milacipran may be useful for OCD therapy.
关键词：milacnipran;antidepressant;marble burying behavior;serotonin and noradrenaline reuptake inhibitor;fluvoxamine