文章基本信息

标题：Lincomycin Protects Mice from Septic Shock in β-Glucan-Indomethacin Model
本地全文：下载
作者：Sachiko Nameda ; Noriko N. Miura ; Yoshiyuki Adachi 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2007
卷号：30
期号：12
页码：2312-2316
DOI：10.1248/bpb.30.2312
出版社：The Pharmaceutical Society of Japan
摘要：We have developed a septic shock model in mice by sequential administration of β-glucan, a biological response modifier, and indomethacin (IND), a nonsteroidal anti-inflammatory drug. Lethality was significantly related to the translocation of gut flora to various organs and mal-adjustment of the cytokine network. In the present study, we have examined the effect of antibiotics on this model to further clarify meanings of microbial flora. Schizophyllan (SPG), antitumor β-glucan for clinical use, obtained from the culture filtrate of Schizophyllum commune , was used to induce sepsis. Lincomycin (LCM), imipenem (IPM), cilastatine (CS), and ampicillin (ABPC) were used for antibiotics treatment. The survival rate of SPG/IND-treated mice was significantly increased by administering LCM or ABPC/IPM/CS, and the effect was more significant by LCM. In in vitro spleen cell culture, LCM decreased proinflammatory cytokine production. Moreover, prednisolone, immune suppresser treatment improved survival of SPG/IND-treated mice. These findings suggest that LCM is an effective antibiotic in this endogenous septic model by modulating gut microbial flora and, at least a part, by regulating cytokine production of leukocytes.
关键词：sepsis;gut flora;lincomycin;indomethacin;beta-glucan;inflammatory cytokine