文章基本信息

标题：Analyses of Novel Prognostic Factors in Neuroblastoma Patients
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作者：Susumu Ootsuka ; Satoru Asami ; Takae Sasaki 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2007
卷号：30
期号：12
页码：2294-2299
DOI：10.1248/bpb.30.2294
出版社：The Pharmaceutical Society of Japan
摘要：Neuroblastoma (NB) is the most common malignant solid tumor in childhood. There are well-recognized prognostic factors in NB such as age at diagnosis, organ of origin, stages, MYCN gene amplification, and expression of H- ras , trk A and survivin. Moreover, we investigated the expression of vascular endothelial growth factor (VEGF), tyrosine hydroxylase (TH), p53, stem cell factor (SCF) and c- kit of its receptor with quantitative real-time polymerase chain reaction (PCR) in 22 NBs and 4 other tumors (one malignant lymphoma, one malignant teratoma, and 2 rhabdomyosarcomas) samples. The correlation between patients' prognoses and the expression of TH or c- kit was newly recognized, particularly the good prognosis in patients in whom c- kit highly expressed and the poor prognosis contrarily associated with low or no expression, although the SCF of its ligand had no relationship with patient prognosis. It is possible that tumors without c- kit expression can not react with SCF ( via the autocrine or paracrine system) and remain immature. It may be that this is a new critical clinical event in NB patients.
关键词：neuroblastoma;tyrosine hydroxylase;stem cell factor;c-kit