文章基本信息

标题：Magnolol and Honokiol: Inhibitors against Mouse Passive Cutaneous Anaphylaxis Reaction and Scratching Behaviors
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作者：Sang Jun Han ; Eun-Ah Bae ; Hien Trung Trinh 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2007
卷号：30
期号：11
页码：2201-2203
DOI：10.1248/bpb.30.2201
出版社：The Pharmaceutical Society of Japan
摘要：The antiallergic effects of magnolol and honokiol, isolated from the bark of Magnolia obovata (family Magnoliaceae), were investigated both in vitro and in vivo . Magnolol and honokiol potently inhibited passive cutaneous anaphylaxis reactions in mice induced by IgE–antigen complex as well as compound 48/80-induced scratching behaviors. These constituents exhibited not only potent inhibitory activity on the degranulation of RBL-2H3 cells induced by IgE–antigen complex, with IC₅₀ values of 45 and 55 μ M , respectively, but also inhibited the protein expressions of IL-4 and TNF-α. Based on these findings, magnolol and honokiol may improve IgE-induced allergic diseases.
关键词：magnolol;honokiol;itching;passive cutaneous anaphylaxis reaction;allergy