文章基本信息

标题：Maslinic Acid Reduces Blood Glucose in KK-Ay Mice
本地全文：下载
作者：Jun Liu ; Hongbin Sun ; Weigang Duan 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2007
卷号：30
期号：11
页码：2075-2078
DOI：10.1248/bpb.30.2075
出版社：The Pharmaceutical Society of Japan
摘要：In the present study, we have examined the hypoglycemic effect of maslinic acid (MA) in KK-A^y mice, an animal model of genetic type-2 diabetes. MA (10 mg/kg body wt) reduced the blood glucose levels in KK-A^y mice at 4 h after a single oral dose. KK-A^y mice receiving MA at daily dosages of 10 mg/kg and 30 mg/kg for 2 weeks showed a significant reduction in the blood glucose levels. Furthermore, the results also showed that MA might modulate glucose metabolism partially through reducing insulin resistance in KK-A^y mice. Taken together, MA may hold great promise as a natural therapeutic agent for treatment of type 2 diabetes.
关键词：maslinic acid;KK-Ay mice;type 2 diabetes;insulin resistance