文章基本信息

标题：Effects of Urocortin, Corticotropin-Releasing Factor (CRF) Receptor Agonist, and Astressin, CRF Receptor Antagonist, on the Sleep–Wake Pattern: Analysis by Radiotelemetry in Conscious Rats
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作者：Masayuki Uchida ; Masayuki Suzuki ; Kimiko Shimizu 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2007
卷号：30
期号：10
页码：1895-1897
DOI：10.1248/bpb.30.1895
出版社：The Pharmaceutical Society of Japan
摘要：Stress has been known to release corticotropin-releasing factor (CRF) and have an affect on sleep–wake patterns. However, there is no direct evidence of CRF receptor agonist and antagonist on sleep–wake patterns. Therefore, this study aimed to clarify this point by using radiotelemetry system in conscious rats. Wake, non-rapid eye-moving (NREM) sleep and rapid eye-moving (REM) sleep were analyzed by computer software, simultaneously measuring electroencephalogram and electromyogram. In the light period, urocortin (CRF receptor agonist: i.v.) significantly increased wake duration, and decreased NREM sleep duration. REM sleep was not affected. Astressin (CRF receptor antagonist: i.p.) significantly attenuated the changes induced by urocortin, although astressin itself did not affect the sleep–wake pattern in the light period at this dosage. These findings show that urocortin changes the sleep–wake pattern in the light period. Moreover, urocortin was found to change the sleep–wake pattern by acting on CRF receptor, as astressin significantly attenuated the urocortin-induced changes on sleep–wake patterns.
关键词：corticotropin-releasing factor;sleep in rat;wake;urocortin;astressin;radiotelemetry