文章基本信息

标题：Antidepressant Effect of Extracts from Ginkgo biloba Leaves in Behavioral Models
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作者：Hiroyuki Sakakibara ; Kaori Ishida ; Oliver Grundmann 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2006
卷号：29
期号：8
页码：1767-1770
DOI：10.1248/bpb.29.1767
出版社：The Pharmaceutical Society of Japan
摘要：Extracts of Ginkgo biloba (EGB) are a complex product prepared from green leaves of the Ginkgo biloba tree. In the present study, the antidepressant effect of EGB was examined using two behavioral models, the forced swimming test (FST) in rats and tail suspension test (TST) in mice. EGB significantly reduced immobility time in the FST at a dosage of 10 and 50 mg/kg body weight after repeated oral treatment for 14 d, although no change of motor dysfunction was observed with the same dosage in the open field test. These results indicate that EGB might possess an antidepressant activity. In addition, EGB markedly shortened immobility time in the TST after acute inter-peritoneal treatment at a dosage of 50 and 100 mg/kg body weight. The present study clearly demonstrated that EGB exerts an antidepressant effect in these two behavioral models.
关键词：Ginkgo biloba extracts;antidepressant effect;forced swimming test;tail suspension test;flavonoid