文章基本信息

标题：Protection against D-Galactosamine-Induced Acute Liver Injury by Oral Administration of Extracts from Lentinus edodes Mycelia
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作者：Aiko Watanabe ; Masakazu Kobayashi ; Shinji Hayashi 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2006
卷号：29
期号：8
页码：1651-1654
DOI：10.1248/bpb.29.1651
出版社：The Pharmaceutical Society of Japan
摘要：The development of oral medications to help prevent liver injury is desirable, and some mushrooms contain chemicals that show promise as such a treatment. Here, we tested whether a hot-water extract (L.E.M.) of the cultured mycelia of an edible mushroom, Lentinus edodes , could protect primary cultured hepatocytes from D -galactosamine (GalN)-induced injury. GalN induced cell death in the hepatocytes, and this effect was completely suppressed by the addition of 0.5 mg/ml L.E.M. Polyphenolic compounds contained in the L.E.M. seemed to be responsible for the protective effect. We next examined the protective effect of L.E.M. in a GalN-induced liver injury model in rats. In rats that had been treated with L.E.M. given orally or intraperitoneally, GalN caused less leakage of aspartate aminotransferase and alanine aminotransferase, markers for liver injury, and a lower decrease in serum protein content, than in non-L.E.M.-treated rats. Histological analysis of the liver also showed a protective effect of L.E.M. Our findings indicate that L.E.M. administration is a promising treatment for protecting the liver from acute injury.
关键词：Lentinus edodes;hepatoprotective effect; D -galactosamine;polyphenol;oral administration