文章基本信息

标题：Evaluation of Calvert's Formula for Dosage Adjustment of Carboplatin in Japanese Patients with Hormone Refractory Prostate Cancer
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作者：Eriko Sato ; Ikuko Yano ; Mari Jiko 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2006
卷号：29
期号：7
页码：1441-1444
DOI：10.1248/bpb.29.1441
出版社：The Pharmaceutical Society of Japan
摘要：For hormone refractory prostate carcinoma, a combination therapy of paclitaxel and carboplatin is used to expect life extention. We investigated the pharmacokinetics of carboplatin in Japanese prostate cancer patients ( n =10, 55—72 years), and evaluated the usefulness of Calvert's formula in the individualized dosing adjustment. They were intravenously administered carboplatin (area under the free plasma concentration versus time curve ( AUC )=5 mg·min/ml), following the intravenous administration of paclitaxel (175 mg/m²). The dosage of carboplatin for each patient was determined with Calvert's formula using individual creatinine clearance values. Plasma concentration of total platinum was measured sequentially and the pharmacokinetic parameters of carboplatin were determined in each patient. Plasma concentration of total carboplatin after intravenous infusion well fitted the two-compartment model. Carboplatin clearance was 62.0±12.7 ml/min (mean±S.D.), and linearly related to the individual creatinine clearance ( r ²=0.64, p <0.01). The actual AUC for total carboplatin was 8.20±1.11 mg·min/ml, and its inter-individual variability was decreased to 65% of that in carboplatin clearance, indicating the effectiveness of Calvert's formula for dosage adjustment of carboplatin. Leucopenia of grade 4 according to the National Cancer Institute's Common Toxicity Criteria was found in one patient, but no patient demonstrated thrombocytopenia. In conclusion, determining carboplatin dosage based on Calvert's formula decreased the inter-individual variability in the actual AUC compared with that in the carboplatin clearance, and a target AUC of 5 mg·min/ml of carboplatin was comparatively safe for Japanese patients with prostate cancer.
关键词：carboplatin;pharmacokinetics;Calvert's formula;prostate cancer;paclitaxel;toxicodynamics