文章基本信息

标题：Inhibitory Activity of Plant Stilbene Oligomers against DNA Topoisomerase II
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作者：Masashi Yamada ; Ken-ichiro Hayashi ; Shogo Ikeda 等
期刊名称：Biological and Pharmaceutical Bulletin
印刷版ISSN：0918-6158
电子版ISSN：1347-5215
出版年度：2006
卷号：29
期号：7
页码：1504-1507
DOI：10.1248/bpb.29.1504
出版社：The Pharmaceutical Society of Japan
摘要：The inhibitory activity of 40 stilbene oligomers isolated from six plant species against topoisomerase II was evaluated, of which nine compounds showed a potent inhibitory effect, stronger than daunorubicin, a topoisomerase II inhibitor, used as an anti-cancer drug. The specificity of active stilbene oligomers on topoisomerase II was assessed by their effect on DNA restriction enzyme. In particular, specific inhibitory activity was observed in α-viniferin 13- O -β-glucopryranoside (2) and hemsleyanol C (13).
关键词：stilbene;topoisomerase;inhibitor